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British Journal of Clinical Pharmacology

November 28, 2019

With their expertise in the safe and effective use of medications, pharmacists can help in the management of chronic diseases. A review and analysis published in the indicates that initiatives—such as patient education, medication review, and physical assessments—led by pharmacists can make important contributions to the prevention of cardiovascular disease....

November 07, 2019

Results from a study published in the may help explain why cannabidiol—a chemical component of marijuana with no psychoactive properties—reduces the frequency of seizures in patients with a severe form of epilepsy. The effect may be explained by a drug-drug interaction between cannabidiol and the anti-seizure medication clobazam....

November 06, 2019

Use of medications during pregnancy is more common in women with preeclampsia than in those without, according to an analysis of women who gave birth at a hospital in Finland in 2002–2016.

In the analysis of 1,252 women who had preeclampsia and 1,256 controls without preeclampsia, 59.5% of women with preeclampsia and 35.5% of controls used at least one drug during pregnancy. In both groups, the most commonly used drugs were antibiotics, hypertensive...

October 09, 2019

Statins have been reported to be beneficial for infections such as pneumonia and Staphylococcus aureus bacteraemia. In the case of skin and soft tissue infections however, statin use is ironically associated with an increased risk of developing diabetes, which is a risk factor for such infections. In a  study, statin use for as little as 91 days was linked with elevated risks of skin and soft tissue infections and diabetes. The increased risk...

September 05, 2019

A recent analysis of published studies examined the clinical consequences of medication adherence. The analysis found that medication adherence is linked with lower risks of needing to be hospitalised and of dying early.

June 05, 2019

There is concern about the misuse of the sedative anti-anxiety medication alprazolam (Xanax®) because of the “high” it can create. A new study found that non-medical use of alprazolam in the United Kingdom is a significant issue, and it appears to be more prevalent in younger adults.

April 03, 2019

In a study, investigators uncovered numerous gender differences in reports of adverse drug reactions sent to the National Pharmacovigilance Centre in the Netherlands.

March 06, 2019

Individuals who take cholesterol-lowering statins may be at higher risk for developing high blood sugar levels, insulin resistance, and eventually type 2 diabetes, according to an analysis published in the .

The analysis examined information from 9,535 individuals older than 45 years of age who were free from diabetes at the start of the population-based Rotterdam Study and were followed up to 15 years....

February 06, 2019

A new review examines the impact of cancer therapies on the skeleton and how to limit bone loss and fractures in cancer patients treated with these therapies.

January 24, 2019

A new study illustrates the benefits of having clinical pharmacists follow up, by telephone, with patients at risk of having medication-related issues after hospital discharge. The aim is to help patients manage their medications effectively.

In the study, patients who received such pharmacist-led, post-discharge telephone follow-up were matched with patients in a control group. All patients in the study had been prescribed multiple medicines for the...

December 05, 2018

Taking opioids for the treatment of pain has been associated with increased risks of crashing among drivers, but it is unknown whether this applies to all opioids or pertains to specific opioids only. A new study found that the influence of single analgesic doses of methadone and buprenorphine—two different opioids—on driving performance was mild and below the impairment threshold of a blood alcohol concentration of 0.5 mg ml-1....

November 07, 2018

In a study of older adults prescribed statins, first-year nonadherence and discontinuation rates were high....

October 17, 2018

In a study of 15 patients affected by major depressive disorder and complaining of insomnia, initiating treatment with vortioxetine for their depressive symptoms led to significant improvements in subjective sleep quality and daytime sleepiness. The findings may have important clinical implications because sleep problems affect an estimated 70 to 90 percent of patients with depression....

October 03, 2018

Cardiovascular calcification is a major health concern in patients with kidney failure undergoing haemodialysis. A first-time-in-human clinical trial of an investigational calcification inhibitor has generated promising results in terms of safety, tolerability, and pharmacokinetics. The findings are published in the .

September 19, 2018

Infection with human papillomavirus (HPV) can cause certain cancers in women and men, but HPV vaccines are highly effective in preventing infection with oncogenic HPV types. A new review of post-licensure data did not identify any new or unexpected safety concerns of the bivalent HPV vaccine.

September 06, 2018

Individuals with advanced lung cancer often have other comorbid conditions, and many may be on complex, costly, and even inappropriate medication regimens. A new study examined the extent to which such patients are prescribed medications with questionable benefit.

August 08, 2018

A new review examines the potential of medicinal cannabis—or medical marijuana—for helping patients with intractable epilepsy, in which seizures fail to come under control with standard anticonvulsant treatment.

July 05, 2018

A recent meta-analysis of published studies has compared the efficacy and safety of antihypertensive drugs during pregnancy.

In the , investigators reported similar efficacy between nifedipine, hydralazine, and labetalol, and negligible differences were observed in their safety profile. The available evidence was inadequate for other drugs. Moderate quality of evidence was observed for direct comparison estimates between labetalol and hydralazine,...

July 02, 2018

Medication-related harm (MRH) is common in older adults following hospital discharge. A new study has examined whether doctors can predict which older patients will experience MRH requiring care following hospital discharge, and whether clinical experience and confidence in prediction influence the accuracy of predictions. 

The study found that clinical judgement of doctors is not a reliable tool to predict MRH in older adults post-discharge....

June 20, 2018

Prescribing of medications has traditionally been restricted to physicians, but there is growing support to allow pharmacists to do so as well. A review of a large number of studies in many countries reveals that diverse groups of stakeholders hold positive views and experiences around pharmacist prescribing....

June 06, 2018

Buprenorphine (BUP) is approved for the treatment of opioid addiction. The current dosing regimen of BUP in pregnant women is based on recommendations designed for non-pregnant adults, but physiological changes during pregnancy may alter BUP exposure and efficacy. As described in a study, researchers have developed a physiologically based pharmacokinetic model that predicts changes in BUP exposure at different stages of pregnancy....

May 30, 2018

A new series published in the (BJCP) aims to help clinicians, researchers, and patients access and understand recent guidelines and regulatory documents issued by the European Medicines Agency (EMA), which oversees the scientific evaluation and safety monitoring of medicines in the European Union.

May 23, 2018

New research indicates that harm from medicines is common in older adults following hospital discharge, and it results in substantial use of healthcare resources. In the study, medication-related harm affected 1 in 3 older adults following hospital discharge, of which 50 percent was potentially preventable.


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May 03, 2018

Salbutamol, also known as albuterol, is a medication that opens up constricted medium and large airways in the lungs and is often used to treat asthma. Because high doses are suspected by some to also have an anabolic effect, its daily dosage is restricted by the World Anti-Doping Agency, which uses urine tests to determine violations. A new study shows that large variability in urine concentrations, however, lead to ...

April 05, 2018

Little is known concerning how extensively drugs are prescribed to newborns in different neonatal intensive care units (NICUs). A new study of nearly 1,500 newborns admitted during 12 months to four different NICUs in The Netherlands found that drug use varies widely.

Cardiovascular and nervous system drugs were most often prescribed off-label in relation to newborns’ age, and their prescription was highly variable between NICUs....

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